Propylene glycol toxicity with lorazepam drip
WebbPropylene glycol toxicity presenting as high anion gap metabolic acidosis and osmolar gap has been extensively reported in literature, and most of them are secondary to intravenous lorazepam infusion. However, propylene glycol is used as a solvent in a number of medications that are frequently utilized in critical care setting, and hence one ... Webb1 mars 2003 · Request PDF On Mar 1, 2003, Richard Arbour published Propylene Glycol Toxicity Occurs During Low-Dose Infusions of Lorazepam Find, read and cite all the …
Propylene glycol toxicity with lorazepam drip
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Webb1 sep. 2015 · OBJECTIVES: To develop and determine the safety of a guideline, by using osmol gap as an indicator of propylene glycol toxicity for pediatric patients receiving … WebbPropylene, also known as propene, is an unsaturated organic compound with the chemical formula CH 3 CH=CH 2. It has one double bond, and is the second simplest member of the alkene class of hydrocarbons. ... Propene has low acute toxicity from inhalation and is not considered to be carcinogenic.
Webb1 juni 2002 · All 13 patients in the high-dose group, 14 (54%) of the 26 in the low-dose group, and none of the 25 controls had serum propylene glycol concentrations … Webb25 juni 2024 · We present a case of iatrogenic propylene glycol toxicity secondary to a high-dose pentobarbital infusion for the treatment of refractory intracranial hypertension …
Webb25 juni 2024 · Propylene glycol is a rarely reported toxicity from high-dose administration of certain intravenous drugs, including lorazepam and pentobarbital. We present a case … Webb1 sep. 2005 · Propylene glycol toxicity: a severe iatrogenic illness in ICU patients receiving IV benzodiazepines: a case series and prospective, observational pilot study. Sign in or …
Webb17 jan. 2012 · Propylene glycol (PG), a component of lorazepam intravenous formulation, was considered the potential source of the metabolic abnormality. The patient received …
WebbEach mL of sterile injection contains either 2.0 or 4.0 mg of lorazepam, 0.18 mL polyethylene glycol 400 in propylene glycol with 2.0% benzyl alcohol as preservative. Close. CLINICAL PHARMACOLOGY. Lorazepam interacts with the γ-aminobutyric acid (GABA)-benzodiazepine receptor complex, which is widespread in the brain of humans as well as … olympus ecg-2Webb1 juni 2002 · IMPLICATIONS We report a case of toxicity from the drug solvent propylene glycol resulting from prolonged, large-dose lorazepam infusion. The case is unusual in … is anthony huber white or blackWebb30 juli 2024 · Propylene glycol is a diluent for several medications commonly used in critical care – especially diazepam, lorazepam, and phenytoin. Although propylene … olympus ecruWebb4 sep. 2015 · Propylene glycol toxicity has previously been reported following accidental overdoses of diazepam and lorazepam in the inpatient setting. 3, 4 The acute clinical effects of propylene glycol poisoning are primarily central nervous system depression and lactic acidosis. 6 Other effects include skin/soft tissue necrosis, cardiac dysrhythmias, … olympus ec-14WebbPropylene glycol is a synthetic liquid substance that absorbs water. Propylene glycol is also used to make polyester compounds, and as a base for deicing solutions. Propylene … is anthony flew a christianWebb1 dec. 1999 · DOI: 10.1097/00003246-199912001-00337 Corpus ID: 72922300; PROPYLENE GLYCOL ASSOCIATED RENAL TOXICITY FROM LORAZEPAM INFUSIONS … olympus ecg-5WebbThere have been reports of possible propylene glycol toxicity (e.g., lactic acidosis, hyperosmolality, hypotension) and possible polyethylene glycol toxicity (e.g., acute tubular necrosis) during administration of ATIVAN Injection at higher than recommended doses. Symptoms may be more likely to develop in patients with renal impairment. is anthony geary still alive