Cisplatin and electrolytes

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August undefined, 2024

WebCisplatin is a platinum containing drug first approved as an antineoplastic agent in 1978. It remains an important and effective therapy in many forms of cancer today. Cisplatin mediates its tumorcidal effects via a number of different cytotoxic mechanisms. Although it is best known for DNA damage, … WebCisplatin and ifosfamide can cause kidney damage. This can be lessened by giving lots of fluids (usually into a vein – IV) before and after these drugs are given. Cisplatin, etoposide, paclitaxel, and vinblastine can damage nerves (known as neuropathy ). This can lead to numbness or tingling in the hands and feet, and sensitivity to cold or heat.

Cisplatin - an overview ScienceDirect Topics

Webdose modification for cisplatin in renal impairment; fluids, diuretics and additives; Hydration regimens reviewed and the following changes made: alternative overnight regimen … WebCisplatin is a coordinate metal complex with significant antineoplastic activity and various effects, including acute anc chronic renal insufficiency and renal … side by side vacation

184-Prevention and management of cisplatin …

WebSep 26, 2024 · While generally mild electrolyte deficiencies are pretty benign, moderate/severe abnormalities can cause many life-threatening conditions, including cardiac arrhythmias, seizures, muscle paralysis, … WebNov 12, 2024 · Commonly reported side effects of cisplatin include: bone marrow depression, nephrotoxicity, and ototoxicity. Continue reading for a comprehensive list of … WebCisplatin is administered through a vein (intravenously or IV) as an infusion. There is no pill form of cisplatin. Cisplatin is an irritant. An irritant is a chemical that can cause … the pines at hathaway pond

Cisplatin (UK PID) - International Programme on Chemical Safety

DailyMed - CISPLATIN injection

WebMar 1, 2024 · A case of an elderly male presenting with significant recurrent hyponatremia, and prerenal azotemia, with recent exposure to cisplatin along with significant hypovolemia and urinary loss of sodium is reported. Cisplatin is a well‐known chemotherapeutic agent that can be associated with hyponatremia. It is known to be associated with a multitude … WebMar 1, 2024 · Lasix is a strong diuretic that increases urination and relieves excess fluid from the body. This may also lead to the depletion of certain electrolytes, such as potassium. 5. Tips Dosages vary from individual to individual and people taking high dosages may need extra monitoring by their doctor. the pines at glen laurel clayton ncWebThe primary outcome was to compare the rate of grade 3 or greater serum creatinine (SCr) increase in patients receiving saline hydration vs. the addition of mannitol; additional parameters of interest included creatinine clearance, electrolyte disturbances, dose changes, and discontinuation of cisplatin. side by side utv with snow blower

"WebAt one hour after cisplatin injection, the intestinal segment was perfused in situ with plasma electrolyte solution (Na 140 mmol/l, K 4 mmol/l, HCO 3 40 mmol/l, Cl 104 mmol/l) … " - Cisplatin and electrolytes

Cisplatin and electrolytes

Cisplatin Uses, Side Effects & Warnings - Drugs.com

WebSep 18, 2024 · Cisplatin is a medication used to manage and treat solid tumors and hematologic malignancies. It is in the alkylating agent class of cytotoxic medications. This activity reviews the indications, action, and … WebFeb 16, 2016 · Purpose: Loco-regional control and organ preservation are significantly improved with concomitant cisplatin/radiotherapy and are compromised with less than 5% grade 3 nephrotoxicity (creatinine clearance 15–29 mL/min). However, although clinically important, in none of the randomized trials is grade 2 nephrotoxicity (defined as …

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WebOct 7, 2024 · Cisplatin is one of the most widely used chemotherapeutic drugs in the treatment of a wide range of pediatric and adult malignances. However, it has various side effects which limit its use. Cisplatin mouse models are widely used in studies investigating cisplatin therapeutic and toxic effects.

WebApr 12, 2024 · As previously described, also the cisplatin can induce electrolyte imbalances. In this case, the standard approach to avoid cisplatin-induced nephrotoxicity and the consequent electrolyte alteration is the administration of IV isotonic saline solution in order to stimulate the diuresis. Some authors suggest to add 2 gr of magnesium … WebCisplatin revealed higher cytotoxicity towards established cell lines. Following CisEP application, we observed a significant decrease of cells viability in the primary culture …

WebNational Center for Biotechnology Information WebSep 27, 2024 · Nephrotoxicity: cisplatin for injection can cause severe renal toxicity, including acute renal failure. Severe renal toxicities are dose-related and cumulative. Ensure adequate hydration and monitor renal function and electrolytes.

WebIts signs include lethargy, vomiting, and general muscle weakness (Anand & Nikhil, 2024). As an electrolyte, calcium helps in keeping bones healthy and a lack of this leads to general tiredness especially on the aged patients. FLUID AND ELECTROLYTE 6 References Anand, A. S., & Nikhil, S. (2024).

WebDec 2, 2014 · Cisplatin is one of the most widely used and highly effective drug for the treatment of various solid tumors; however, it has dose-dependent side effects on the kidney, cochlear, and nerves. Nephrotoxicity is the … side by side vehicle gameWebNephrotoxicity: cisplatin for injection can cause severe renal toxicity, including acute renal failure. Severe renal toxicities are dose-related and cumulative. Ensure adequate … side by side vehicle qldWebFeb 16, 2024 · severe or ongoing nausea and vomiting; vision problems, pain behind your eyes; hearing problems, ringing in your ears; pain, redness, swelling, or skin changes … the pines at gahagan summerville scWebJan 1, 2015 · Background: Cisplatin, one of the most commonly used chemotherapeutic agents, has electrolyte imbalances as one of its most important adverse effects. We conducted this study to characterize... side by side vehicle costWebCisplatin is a platinum-based agent whose nephrotoxicity is thought related to the chloride in the cis position. Cisplatin gains entry into tubular cells via uptake by the OCT-2 … the pines at glenwoodWebElectrolyte imbalances and Cisplatin — Cancer Survivors Network Home › Head and Neck Cancer Electrolyte imbalances and Cisplatin buzz99 Member Posts: 404 October 2010 … the pines at grandviewWebCisplatin solution for injection: Clear, practically colourless solution in amber glass vials containing cisplatin 1mg/ml, sodium chloride 9mg/ml and mannitol 1mg/ml with a pH of 3.5-4.0. 2 SUMMARY The principal target organ for cisplatin toxicity is the kidney. the pines at hemming village